
At the heart of 21st-century urban transformations, understanding the unique essence of each city has become crucial. From technological innovation to sustainability, mobility and tourism, cities face unprecedented challenges that require adaptive and resilient strategies. It was in this context that the CityDNA Autumn Conference 2025 in the Faroe Islands brought together global experts to discuss innovative urbanism and sustainable development. The DNA of Cities is an outcome-led advisory practice helping cities and destinations to unite, evolve and prosper in rapid eveolving time. They work with local partners in cities to optimise that DNA internally and externally over multiple cycles.
Dr Caitlin Morrissey, Co-host of The DNA of Cities podcast, shared her vision on how a city's intrinsic traits – its “DNA” – shape urban policies, strengthen resilience and drive innovation. The podcast has almost 25,000 global downloads and features over 120 local and global city experts. In this exclusive HQ interview, she explores how community participation, local culture and leadership can transform cities into integrated ecosystems, prepared to thrive in an ever-changing world.
The DNA of Cities is what makes every city an individual. We think that if we can see, trace and understand how cities become unique, then we can find ways to optimise their traits as they evolve over multiple cycles. We can help cities to be more themselves. The same policies and projects will not work everywhere. Effective long-term development must start from a deep understanding of the city or destination itself.
We suggest that there are three types of traits that manifest and combine uniquely in every city to give its own unique ‘genetic code’:
We suggest that every city has its own DNA. This has three elements:
All cities, not just the so-called global cities, share these risks. In many domains, we have become conditioned to understand cities, sectors, places and spaces through comparison but our work encourages a different set of conversations. Our approach emphasises the specificity and uniqueness of individual cities, including how a city experiences and responds to vulnerabilities. We ask questions like, what are the challenges that this city faces? Where have they emerged from? Who has been more or less affected, and why? How has the city been resilient in the past? How has its citizens reacted and responded shocks or a long-term traumas? What is the adaptive capacity of this city?
For example, when we made three podcast episodes to explore The DNA of Mexico City, eleven wonderful experts joined us and revealed that residents of Mexico City have acquired a strong survival instinct to equip them for the everyday vulnerability of living in this beguiling and fascinating megacity located at high altitude on a sinking lake bed, surrounded by volcanies and at risk of earthquakes.
.jpg)
A quiet but increasingly recognised risk of 21st century urbanisation is the erosion of distinctiveness, as cities and places increasingly look and feel alike. Sustainable growth that aligns with authenticity or integrity occurs when leaders don’t just have a compelling and shared vision about what they want the destination or city to become, but they understand its carrying capacity, social contracts, governance and heritage. We advocate for this inside-out understanding because it helps those leading cities and destinations to become more conscious of their own capabilities, which then informs their visioning and their action.
Glasgow and Barcelona are examples of two European cities that have hosted specific events in order to enlarge their capacity to host other events: Glasgow’s hosting of COP26, for example, catalysed events and initiatives focused climate finance and just transitions. Another positive example comes from Vienna with their Optimum Tourism strategy, which was crafted based on a recognition of Vienna’s DNA and an understanding of the delicate social contract around tourism which maintains that tourism is good only when it works for the whole city.
When we ask the local experts in our podcast ‘What are the greatest discoveries or inventions in this city?’ their answers reveal a lot about the culture of innovation. It looks different in every city. I have already described Mexico City’s survival instinct which also includes within it a proven and incredible ability to improvise at scale. In Philadelphia, we heard about the invention of public libraries, fire services and several other civic services. In some cities, the strong presence of a university or of an industry has provided deep roots for discovery and invention, but in every city, there is a high degree of everyday innovation that has many, many expressions that is shaped by, and shapes, the city’s identity. This is why some of our guests, for example in Istanbul, describe the city itself as the greatest invention.
The social value of conferences and business events for local communities should be part of their very fabric. Business events and high-level conferences are not just about hosting events that provide a sectoral match in a destination or a city, but ensuring that there is a positive spatial and social purpose to the event that aligns with the values of that place. That can range from skills and training to thoughtful urban design tactics to integrate event venues with their surroundings.
The sector has potential to support all cities to advance their long term sustainable growth goals, but this needs collaboration and coherence. High level conferences and other business events can catalyse long term agendas and strategies that are based on existing strengths, and it can deepening already existing ecosystems. They can provide an opportunity to for new, direct linkages between small growing companies and large companies for procurement or collaboration. The visibility of high profile conferences can help to position the city locally, nationally or internationally promoting it within clusters or expertise, which may catalyse spillovers in locally aligned sector strengths. Major conferences can also provide an opening for new kinds of institutional collaboration and engagement, or it may create a new platform for conversations between resident, civic, industry and government stakeholders.

Storytelling and visioning are ways of convening and motivating at a higher level of partnership, a coordination mechanism for partners within and outside the city. When destinations share the best version of their own story, they are able to attract interest that is more related to who they are. What is most important in these stories is their people, which means that there must be ways for them to contribute and to co-create that story.
One of the key takeaways from my keynote speech at the CityDNA Autumn Conference was the commitment of European DMOs to their residents. In our work, we suggest that once people begin to feel that they understand the character of a city and its evolution, we can begin to ‘place’ ourselves in the city’s story. This is very important for established populations, new residents and visitors because it helps to create a sense of identity anchored in values and behaviours that are real and not based on trends or comparisons.
From our perspective, there is no single “ideal” blueprint or model. Every city has the opportunity to define its own role within the destination economy. To do so, it must establish a clear and distinctive positioning, as well as its level of ambition, in order to shape a shared vision that serves its citizens.
We know that the future of destination economies will encompass all the elements you have outlined. While that future remains uncertain, adopting a more holistic approach will enable destinations to maximise their existing carrying capacity while attracting additional capabilities they may not possess internally – effectively connecting the inside out with the outside in.
Published by Meeting Media Company, the publisher of Headquarters Magazine (HQ) – a leading international publication based in Brussels, serving the global MICE industry and association community.
Since its founding in 1992, Meeting Media Group, publisher of Headquarters Magazine (HQ), has been a trusted guide and voice for associations and the global MICE (Meetings, Incentives, Conferences, and Exhibitions) industry.